The Walker Group

Principal Investigator

Professor Gilbert C. Walker
Professor Gilbert C. WalkerPrincipal Investigator

Prof. Walker is the Canada Research Chair (Tier 1) in Biointerfaces. He received his B.A. in Chemistry and Mathematics from Bowdoin College in 1985, and his Ph.D. in Physical Chemistry from the University of Minnesota in 1991. In 1993, he became an assistant professor at the University of Pittsburgh and was later promoted to associate professor in 2000. Walker joined the University of Toronto in 2005 as the Canada Research Chair in Molecular Microscopy and Nanophotonic Devices.

Walker’s research initially focused on ultrafast solvation dynamics and charge transfer in water. He later opened a new area of research in scanned probe microscopy of surfaces and single molecules at surfaces, making a breakthrough, fundamental measurement regarding hydrophobic hydration. Combining optics and mechanics, Walker has developed techniques for chemical imaging and mechanical mapping with nanometric resolution. Moreover, he has created a tool to rapidly acquire infrared spectra on the nanoscale, which he is using to probe surface phonon polaritons in low-dimensional materials. Finally, Walker is using metal nanoparticles as surface-enhanced Raman scattering beacons for the multimodal imaging of cancer cells and structural investigation of proteins related to Alzheimer’s disease.

Student Researchers

Samantha McWhirter
Samantha McWhirterPhD Student
Sam is prototyping phospholipid-encapsulated gold nanoparticle probes for the detection of cell surface proteins on abnormal B lymphocytes using dark-field microscopy and confocal Raman spectroscopy.
Caroline Pao
Caroline PaoPhD Candidate
Caroline is developing silica-encapsulated gold nanoparticle probes that quench background fluorescence for improved detection and imaging of abnormal lymphocytes using dark-field microscopy, Raman spectroscopy, and flow cytometry.
Nashmia Zia
Nashmia ZiaStudent
Nashmia is working on the development of SERS tagged drug loaded nanoparticles for targeted therapy of acute myeloid leukemia
Kelsy Yuan
Kelsy YuanPhD Student
Kelsy is working on synthesizing the phospholipid-encapsulated silver nanoparticles and studying the conformations of different types of membrane bound proteins by using Raman Spectroscopy and Surface Enhanced Raman Spectroscopy.
Monika Satkauskas
Monika SatkauskasPhD Student
Monika’s research interests lie in the fundamental principles of protein folding. She uses single-molecule atomic force microscopy to determine the effect of salts on polymer and peptide hydrophobic hydration.
Ilias Halimi
Ilias HalimiPhD Student
Ilias Halimi is interested in nanoscale characterization of materials. He is currently working with the PeakForce IR.
Logan Zettle
Logan ZettleResearcher
Logan is currently investigating the modulation of receptors on the surface of leukemia cells and how it affects their phagocytosis, using fluorescence microscopy and flow cytometry.
Phoebe Chan
Phoebe ChanPhD Student
Phoebe is developing a hand-held device to detect the receptor-surface spike protein interaction of the SARS-CoV-2 virus, hence detect the presence of the virus in wastewater and aerosol via surface-enhanced Raman spectroscopy, using gold and silver particles.
Yi Fang (Henry) Lai
Yi Fang (Henry) LaiGaduate Student
Yi-Fang is studying directed collisions that lead to selective reaction of hydrocarbons at surfaces.
Guillermo Lozano Onrubia
Guillermo Lozano OnrubiaPhD Student
Guillermo is developing a combined Kelvin probe and nanoscale IR technique to examine perovskites.
Jessica Ye
Jessica YeUndergraduate Student
Jessica is editing manuscripts.
Tiffany Pong
Tiffany PongUndergraduate Student
Tiffany is undertaking Raman spectroscopy of macromolecules near plasmonic nanoparticles.
Mia Zakaria
Mia ZakariaUndergraduate Student
Mia is investigating immune responses in skin cells.
Sierrah Augustin
Sierrah AugustinUndergraduate Student
Sierrah is developing a project on nanoparticle-mucus interactions and keeps a blog at https://sierrah-augustin.medium.com/

Postdoctoral Researchers and Research Associates

Lydie Leung, PhD
Lydie Leung, PhDResearch Associate
Continuing her work with Prof. Polanyi and recently with the Walker group, Lydie is identifying and exploring new examples of a recently discovered controlled reaction types in which only selected impact parameters result in chemical reaction. Essentially, a surface guides projectile reagents along substrate atoms rows to head-on collisions with target reagents. She is focused on two characteristic subclasses: an addition reaction and a ‘knock-on” reaction.

Olga Tatsiy, PhD
Olga Tatsiy, PhDPostdoctoral Researcher
Olga has over 10 years of experience working with complex science projects focusing on immunology, molecular biology, and bioinformatics. Well versed with the latest technologies and tools. Currently, her project is focusing on gene regulation and signal transduction in the immune system and the mechanisms of macrovesicle production by various cell types.
Weiqing Shi, PhD
Weiqing Shi, PhDPostdoctoral Researcher
Weiqing is working on characterizing protein conformations on hydrophobic and hydrophilic surfaces, by collecting information about their secondary structure using surface-enhanced Raman spectroscopy.